I use my Defensive Tackles. I currently have an 88 over Chris Jones (power up) and a 91 over team captain La'Roi Glover. I'm having very good success getting to the QB. Also Before the play I double click my right bumper (PS4) which puts my outside Linebackers into QB contain mode So if I do not get to the QB with a DT a lot of the time one of them will. This works very well if the QB leaves the pocket at all , one of them will pounce on him. I currently have an 88 Lawrence Taylor (power up) at ROLB and an 89 Bobby Bell at LOLB.
NOTE: This is in head to head online play. In solo battles on the hardest difficulty I get sacks 90% of the time.