i had been dealing with this issue since the game was released...actually returned my purchase twice, then they had the price drop for the loyalty price on origin and i bought it again. I found if I run it on directx 12, then it works ok. The issue persists for the first user play of a game, whatever that ends up being depending on your sim, but only stutters for like a second then recovers just fine from there. Keep in mind, I'm running Windows via Bootcamp on a 2018 Macbook Pro.
EDIT: specs and settings info for me is as follows
Hardware 2018 Macbook Pro 15"
intel i9
AMD Radeon Pro 560X
16gb Ram
500gb m.2 ssd
display settings
2800x1800 with 200% zoom
Edition Windows 10 Pro
Version 21H1
Installed on 8/22/2021
OS build 19043.1266
Experience Windows Feature Experience Pack 120.2212.3920.0
M22 graphics settings:
RESOLUTION: 1920X1200
WINDOW MODE: FULLSCREEN
ANTIALIASING: FXAA
FRAMERATE: AUTO
HDR: OFF
VSYNC: ON
TRIPPLE BUFFERING: ON
DIRECTX VERSION: 12
Rendering Quality: Custom (everything is auto down to the DOF)
High Res Circular DOF: OFF
Mesh Quality: ULTRA
Shadow Quality: Medium
Crowd Quality: Medium
*Additionally, I checked my system folder and found duplicates of some dll files.
These files are part of the C++ update from what I understand and removing the duplicate files seems to have helped alot of stuff can't say if that's what fixed Madden, probably not, but here's my list.
SYSWOW folder:
msvcp140.dll
vcruntime140.dll
SYSTEM 32 Folder:
msvcp140.dll
vcruntime140.dll
There is a 32 bit file and 64 bit for each of those. You have to make sure the 64 bit version goes into the system 32 file and the 32 bit goes into the SYSWOW folder...yeah sounds backwards, but that's how that works.
Hope this helps. I was struggling to troubleshoot that since it was released and only just got it running smooth a couple weeks ago.