I use adjusted sliders so i cant rely on the computer to change my lines at all.
I usually roll all 4 lines. I tend to roll my top 2 lines more often. It took a little bit of work but I'm so good at it now that at the end of games I can look at Time on Ice for all my players and it works out pretty well that my best two players (Datsyuk and Zetterberg) as well as my top 3-4 defensemen are the leaders in time on ice with the 4th liners that dont provide much with the least amount.
I do bring in the 4th line to occassionally drop the gloves too
Even though there really isn't any sort of momentum factors installed in the game, I like to pretend there is and try to be more offensive there after.