Exactly, give your defender who is manned up on the RB a fighting chance to make a play. If you have a good athlete on defense and can sacrifice the coverage somewhere else, this usually does a pretty nice job. Following up with another manually controlled defender of your own should seal the deal most the time and get a tackle for loss on him. Remember, most kids who force screens all game don't have much past that. Once you lock the repetitive things down, usually people are left treading water and guessing. This is where sacks/INT's come
Basically, in general man coverage plays should do well against screens, zones, especially deep zones, should struggle. blitzes with man coverage might struggle, and zone blitzes should get annihilated by screens (that is actually the strongest counter).
If you can get a good athlete manned up evenly on the RB and get a defender in the flat with him, this play is gone. (If you use Linebacker hot routes, select the Outside Linebacker you want to hot route and flick the R stick down, it will put the linebacker in a flat coverage... that coverage can be nice for passes to the flats ex. screens and quick RB passes.