Yes I think so, also by the CPU run defense sliders..
The biggest thing here is pass and run reaction sliders are backwards.
Make sure you set CPU run reaction to at least 80+ drop block shed to 0, this should open up your run game. I also have human run blocking to 100 also
If only the supersim was alot better and the accel clock worked, my last qb player game 10 mins quarters 15 run off against the CPU colts Andrew luck was 1/5 4 yards and there running back had 33 carries for 87 yards .
this is all madden as well.