I'm no sliders guru but I have played multiple games and have tweaked to the point where I feel like I have a decent slider starter set. Give them a go if you like and certainly tweak to your liking and leave feedback for the rest of us. Please note, these sliders are for the VITA game only.
All-Pro difficulty Slow Speed
10 minute quarters with 20 minimum
Threshold at 50 and I have not messed with this any.
Passing User / CPU
QB Acc. 47 / 63
Pass Block 51 / 62
WR Catch 52 / 56
Rushing
Broken Tackle 50 / 52
Run Block 50 / 53
Fumble 50 / 50
Pass Defense
Reaction Time 37 / 53
Interceptions 37 / 37
Rush Defense
Reaction Time 47 / 50
Block Shed 46 /50
Tackling 47 / 50
Special Teams
FG Power 43
FG Acc. 45
Punt Power 42
Punt Acc. 60
Kickoff Power 48
Penalties
Offside 60
False start 57
Holding 54
Facemask 54
Pass Int. (Both) 100
KR /
PR Int. 65
Clipping 72
Int. grounding 90
Roughing passer 52
Roughing kicker 55
Set your auto subs as you would like, there are several sets on these forums that work nicely. I have my fatigue set at 60 but may actually lower that.