I also play with the Lions so Ill give you my two cents.
1) The Detroit line is very bad. Therefore, I suggest running with a fullback and maybe an extra tight end. There are many plays like this in the middle of the playbook if you search for inside running plays.
2) Establish a play action. Run a lot of short play action plays to counteract any run blitz you might see, and this will help open up the field anymore.
3) Once you have dominated the middle, try a toss play. I prefer the HB crack I think it is because of its blocking scheme, but that way you can just mix it up.
Ive noticed the computer in this game is very alert to tendancies, so you need to make sure you balance out your run/pass.