Nope just watch from opening kick off till the finish. Adjustments have never seemed to stick. Sometimes I'll change a QB or other player if they are struggling BAD. Usually a QB/RB for a fresh look. You can manually sub backups in and it sticks. That's the only other sub I'll make. As far as playcalling, its REALLY playbook dependent. Sometimes I'll see teams run plays evenly other times throw it 60 times and run it 10 times. It's hard to gauge right now. OFF Aggressiveness in the coach settings do not dictate run/pass ratios so I don't even know. It's just test every playbook that works best within your scheme and hope for the best.
I.e. Like Air Raid books, some throw it more and some have a balanced attack that gets 2 - 4 running backs involved depending on your auto subs and depth chart. San Jose is my fav for this reason.