Yes, I understand, but most defenses in this alignment will have the Safety/Nickel back mirror the strong side of the offense. If the offense comes out with 3 WR, 2 of them to the right, I would imagine the defense would flip this play to match up the Safety/Nickel back with the slot WR.
Also, if the offense does come out in that formation, more than likely, the slot WR would line up to the field side. Of course I'm talking real life here, I'm aware that strong and weak don't exist in Madden/NCAA.