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She might have had a rare genetic condition like John Ritter, so I wouldn't jump to drug abuse just yet. And even though she's never been overweight, that doesn't mean she was healthy. I've known a few people who were unhealthy (very large though) who died of heart attacks in their 20s, so if she just ate junk and fast food (which wouldn't surprise me, have you seen her husband?), that might have played a role too.
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