I'm hoping that they'll officially announce harmony in Rock Band: Beatles. Even just 2 mics would be awesome. Four would blow my mind
Madden Online dynasty will be big news when EA (officially) announces it.
Hopefully Microsoft will officially announce a release date for the Live Arcade version of Magic: The Gathering.
I'm looking forward to more info on Bioshock 2.
I'd like to see a release date for Max Payne 3, though I don't think it will come out until at least 2010.
I'm also really excited for the debut of 1 vs 100 on XBox Live tonight at 10:30 PM EST. Hopefully it's cool. I will be on Live tonight until it crashes the servers